Today was our semi-annual visit to the Neurologist at the KU Medical Center’s Movement Disorder’s Clinic. Dr. Pahwa is a national level Neurologist specializing in Parkinson’s Disease. We have struggled mightily with this disease every time we have not been seeing either Dr. Koller before him or Dr. Pahwa. Geography and insurance interfered with access to KU Med for a number of years during the twenty-two since Mary Ann’s diagnosis.
We are pretty well convinced that we have the best care available. That is both good news and bad news. It is good news since we have access to the latest and most effective treatments. The bad news is that there is not much else we can do to improve Mary Ann’s ability to function. This is the best we can expect.
Today, we reviewed the medications. We reported on the changes that have been made. At Mary Ann’s request, we reduced the dosage of Sinamet, the primary medication that treats the motor symptoms of Parkinson’s. It is the same medication that has been used for decades. With all the promising research projects going on, and the various news stories touting a potential cure, not much has changed since the middle of the last century in treating Parkinson’s.
The benefit of reducing the medication is that it has lots of side effects. Since reducing the dosage Mary Ann has had fewer and less intense hot flashes that are shorter in duration. There is a little less of the dyskinetic movements (as seen in Michael J. Fox) during the day. Dr. Pahwa confirmed that change to be appropriate. That is a medication that often is left to the patient to determine how much is taken. Those changes are done within the range acceptable to the Neurologist.
I reported the increase in the Midodrine to keep Mary Ann’s blood pressure high enough to reduce the fainting spells (Orhostatic Hypotension) to a more manageable level of intensity and frequency. The change in that medication was done in consultation with our Cardiologist, who prescribed the Midodrine.
We talked about the increase in hallucinations and their interference with sleeping. As expected, he suggested a small increase in a medication called Seroquel. He reminded us that one problem with increasing the Seroquel is that it can make the blood pressure problem worse. Again, we are riding on a tiny margin between side effects battling one another. We are in hopes that the contest will end in a draw.
I made the mistake of mentioning something about the online Lewy Body Dementia spouses’ group and information about the Autonomic Nervous System I researched on the Internet. I can only guess that he is frustrated with Patients and Caregivers who second-guess his recommendations based on the often bad information. I just made the observation that in looking up what the Parasympathetic side of the Autonomic Nervous system governs, the list included pretty much every area in which Mary Ann has a problem. He was not rude, nor did he say anything much in response. He just moved on to closure of the appointment.
I trust his knowledge and experience. I just recognize that the more we know about the disease, the better we can do at dealing with multiple doctors and the more likely we are to make good decisions by actually understanding the options and their implications. That knowledge has been especially helpful when Mary Ann has gone to the Emergency Room and/or has been hospitalized. The medical professionals there deal with such a variety of problems that they can’t possibly keep up on the details of all of the various diseases.
The next appointment is six months from now. We will see if the increase in Seroquel has a positive effect. Dr. Pahwa is willing to increase the dosage more if this does not work. He increased the dosage from 100mg to 125mg. He suggested that we move to 150mg if the smaller increase doesn’t move the hallucinations back to a level that does not interfere with sleep. That decision is in our hands.
At the moment, we seem to have the best of what is available to deal with the Parkinson’s and the Dementia. While we would like to have a better quality of life, our job is to make the best of what we have.
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December 17, 2012 at 5:44 am
My mother was just recently put on midodrine. Upon reading of the side affects I became concerned and havn ‘t given it to her yet. Could you comment on this. Thank you.
December 17, 2012 at 11:27 am
It would not be appropriate for me to comment on what you should do inyour mother’s case, but I can tell you how we made the decision when to use it and when not — and why. Midodrine’s purpose in Mary Ann’s case was to raise her blood pressure so that she would be less likely to faint since her Parkinson’s had diminished her body’s ability to raise it quickly enough when standing up. Our dilemma was, keep her BP too high or remain seated or lying down, giving up mobility entirely. It was for us simply a matter of risk management. She used the lowest dose that allowed her to get up and walk without fainting. The higher blood pressure may have shortened the duration of her life, but the Midodrine allowed her some modicum of quality during the last couple of years.
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January 1, 2013 at 8:22 am
Hi Peter thank you so much for your reply. The dr is starting her out on a low dose 2.5 mg. You haven given me the courage to try this. Did you use other methods of raising bp such as compression stockings , more salt in diet. I have also read that there has been success using phenylephrine for raising bp. Thanks again. Cathy
January 3, 2013 at 1:22 pm
Cathy,
We did not use compression stockings because Mary Ann was not interested in using them. Your Mother might be okay with it. They would probably be helpful, I have had no experience with them. Mary Ann had suffered from congestive heart failure, so salt was an issue. She was so very limited in what foods she liked that we were grateful to hear that she could add back some salt to help raise her BP (a slice of pizza was her favorite lunch). We finally convinced the Cardiologist to remove the diuretics that had been prescribed to reduce fluid retention after her bout with congestive heart failure. When the last diuretic was removed, she did much better and the episodes of fainting were reduced. There was one BP med that we retained. It seemed odd to be taking a med for hypertension to lower BP and the Midodrine to raise it, but the BP med also reduced the heart pain from a couple of major artieries on her heart that were blocked (needless to say she was not a good candidate for bypass surgery).
Phenylephrine was not one of the options suggested by the doctor and I did not research it. Pyridostigmine was one that we tried, but she did not tolerate it well, and it didn’t seem to help. Of course the matter of managing the risks and side effects is a key component of any decision about the meds. We walked a narrow margin of functionality between the life shortening effects of meds and quality of life effects. My perception is that we struck a balance that was about as good as we could get with the info we (and the docs) had. You seem to be working with the same goals we had. None of the options is perfect.
Peter
January 20, 2013 at 8:02 am
Hi Peter, thank you so much for replying. I still have been reluctant to use midodrine for Mom, but I think that I must start it. Some days are good, some days are bad for OH, but I think I need to strike a more even balance. I know it is very upsetting for her to feel like that, and I think she is reluctant to walk because she might fall. We always have a caregiver with her. Winter months are tough. Did Mary Ann have many side affects from the drug? Thanks Peter. Cathy
January 20, 2013 at 8:57 am
Cathy, I don’t remember identifying any side effects, just the higher blood pressure that was it’s intended purpose. As I mentioned, it was uncomfortably high, which has its own risks. We were in risk management and quality of life mode. Peter
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March 1, 2013 at 6:42 am
hi peter, I still haven’t tried the midodrine for mom yet. Her family dr. keeps discouraging me so I am so confused. She said she has two patients that ended up in the hospital, but I don’t know if they had pd or other bp problems. we visit the neuro in march again so hopefully he can reassure use. I feel bad that I haven’t started the med. I hate this disease. cathy
March 1, 2013 at 11:27 am
It is worthy of your hatred! The lack of consistency and predictability are maddening. What works for one will not work for another. There is no certainty in decision making. The doctors have so mostly technical information and snapshots in their minds based on the few minutes they are with the patient. They are trying to be responsible and make the right recommendations, but some of the time, they are useless because they don’t know any more than we do. Those of us who live with it day by day are the experts on our Loved Ones. We just don’t have the medical knowledge to help us weigh the decisions. It was very helpful to us that we had one of the best Neurologists in the nation who focused attention almost exclusively on those with Parkinson’s. Most Neurologists are dealing with a range of diseases in their specialty and cannot stay at the top of their game in all of them. A sampling of two who ended up in the hospital is not necessarily adequate to determining how to proceed in your Mom’s case. Our Cardiologist is the one who managed the Midodrine rather than the Neurologist although both were fully aware of what the other was doing (through me — they had no direct contact). My struggle and yours too is that sense that you have your Mother’s life in your hands. You feel as if every decision is a life and death decision. The truth is, you don’t own that responsibility. There is no knowing what will happen and what role a particular med might or might not have in whatever happens. All any of us (including the doctors) can do is take our best guess based on the information at hand. There is no perfect “right” decision to be found, at least none accessible by mere humans. I am sure that Mary Ann and I (especially me) made dozens, hundreds, of wrong decisions by some standard or other. They were just the decisions we made. We were just ordinary people with limited knowledge and it was our life to live. At this point now that she is gone, I have accepted my guilt for not being a better spouse and smarter amateur physician, and more skilled caregiver. I loved her and tried to do the best I could with the information available. That is all that was within my power. Your Mom will not live forever and that is neither her nor your goal. The goal is live meaningfully with the best quality of life possible with the meds and tools available. Working at that is enough. The matter of life and death is not yours to decide. If you had that power, long ago you would have made the disease go away. Sorry to be lengthy in my reply, but I have thought long and hard about my role. I know something of the struggles you are experiencing. Peter
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